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But not, the existence of ectopic calcification in the Achilles, patellar and quadriceps tendons was also stated within the biglycan and you will fibromodulin knockout mice 53. Another important ability out of SLRPs is their capability to modulate the brand new pastime of one’s resident telephone populace by the binding and you will sequestering gains issues 54, 55. The brand new distinction of tendon progenitor cells to the chondrocytes and you can bone cells is modulated because of the term of biglycan and fibromodulin 56. It may be modulated because of the expression out of biglycan and fibromodulin, and by the term from chondro-ostogenetic BMPs, such as BMP-2, BMP-4 and you will BMP-7, that have been over-expressed within the CT patterns 57.

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